Design and Functionalization of Graphene Oxide Nanoplatforms for Targeted Neurotrophic Delivery and Theranostic Applications.

This traineeship focuses on the design, synthesis, and functionalization of graphene oxide-based nanoplatforms for theranostic applications, with an emphasis on exploiting the nanozyme properties of functionalized graphene oxide. The project involves loading the nanoplatforms with neurotrophic factors, including BDNF(1-12), NT3(1-13), and NGF(1-14), both in their native and fluorescently labeled forms (FAM). These nanoplatforms will be engineered to enhance therapeutic delivery and enable precise diagnostic imaging, leveraging the catalytic properties of graphene oxide for targeted drug delivery and real-time monitoring. Various spectroscopic and microscopic techniques, including UV-Vis, fluorescence, FTIR, and atomic force microscopy (AFM), will be employed to characterize the nanoplatforms and their interactions at the molecular and cellular levels. This multidisciplinary approach combines advanced materials science, biophysics, and cellular biochemistry to develop innovative solutions for therapeutic and diagnostic applications.

Contact: Prof. Cristina Satriano (cristina.satriano@unict.it)