Fidia Farmaceutici S.P.A. (Siracusa, Italy), Universitè Libre de Bruxelles (Belgio), IONICS (Belgio).
An emerging approach for care and regenerative therapy of chronic wounds, which have an increased incidence in elderly, diabetics, immuno-suppressed and immobilised people, uses smart hydrogels for a spatio-temporally triggerred repair process. Hyaluronic acid (HyA)-based dressings are already safely used, e.g., in treating diabetic foot ulcer. The novel multifunctional HyA-CAR(GHK)-Cu dressing, deposited via an atmospheric plasma technology ad hoc designed and developed, starts from HyA conjugated with a dipeptide (carnosine, CAR) and/or a tripeptide (GHK), exhibiting inhibitory effects against carnosinase as well as antioxidant and anti-inflammatory properties. The scaffold is further implemented by the incorporation of copper, which has angiogenic and antibacterial properties, as well as SOD-like activity in the CAR-Cu and GHK-Cu complexes. The HyA-CAR(GHK)-Cu hydrogels will provide a novel unique synergic activity in the modulation of the wound healing and scar repair actions.