University of Catania
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AdvaNced Technologies for Human-centrEd Medicine
national research
PNRR – Investimenti complementari
DD 931 del 6 giugno 2022 - Avviso per la concessione di finanziamenti destinati ad iniziative di ricerca per tecnologie e percorsi innovativi in ambito sanitario e assistenziale finanziato a valere sulle risorse previste dal Fondo complementare al Piano Nazionale di Ripresa e Resilienza
Main ERC field: 
Life Sciences
Unict role: 
Duration (months): 
Start date: 
Sunday, January 1, 2023
End date: 
Friday, January 1, 2027
Total cost: 
€ 125.223.504,30
Unict cost: 
€ 12.852.095,00
Università degli Studi Milano Bicocca
Principal investigator in Unict: 
Prof. Giovanni Li Volti
University department involved: 
Department of Biomedical and Biotechnological Sciences
Department of Drug Sciences
Department of Medical and Surgical Sciences and advanced technologies
Department of Physics and Astronomy
Department of General Surgery and Medical-Surgical Specialties
  • Università del Salento
  • Università Vanvitelli
  • Università di Messina
  • Politecnico di Milano
  • Università della Calabria
  • INFN
  • Hunimed
  • Centro IOM
  • Azienda Opedaliera Cannizzaro


The aim of this spoke is to develop innovative therapeutic solution, with the potential to be a response for those tumours that cannot be treated with conventional approaches. To this regard, the pilots dedicated to these innovations will take advantage of new developments in the drug delivery methodologies pursued by other pilots.

In particular, the main objective of the spoke is the realisation of a BNCT facility in Caserta, using technology, informatics and nuclear physics methods already available at INFN completed by the biological and clinical expertise of UNICAMP. UNICAMP will be responsible for constructing the bunker and its services while INFN will realise the high-technology part. Installation and commissioning will be a common activity.

Research teams will address the necessary steps to integrate the technology and the preclinical studies to enlarge the knowledge on the interaction of a mixed radiation field with biological tissue. To this end, a set of preclinical radiobiological evaluations will be carried out by UNICAMP using existing neutron facilities while INFN will complete and install the necessary technology to produce the neutron beam. Targets will be GBM, but also head&neck, gastrointestinal, genito-urinary and gynaecological tumours based on the natural sensitivity to the radiotherapy.