PlasMaRe

The MARE project is embedded in an integrated research and innovation strategy within a One Health framework, aimed at developing advanced platforms for the monitoring, analysis, and clinical translation of therapeutic and diagnostic solutions. Within this structure, the DOMARE and PLASMARE actions operate in a complementary manner to enhance the expertise, infrastructures, and outcomes generated within the PNRR programs, with particular attention to building technological value chains in digital health, epidemiological surveillance, and drug discovery.

Within this framework, the Department of Chemical Sciences contributes through the PATCH activity, located in WP6 – TECMARE, which is dedicated to the development of antibiotic polymers for skin treatment and wound healing. PATCH aims to optimize hyaluronic acid-based hydrogel films, previously characterized within the INF-ACT program, for the controlled release of antibiotics and their application in the treatment of complex wounds. This line of research addresses a major clinical challenge: in Europe, more than 40 million patients require specialized care for surgical wounds, burns, and chronic ulcers, generating an annual cost exceeding 20 billion euros.

The scientific relevance of the activity lies in overcoming the limitations of conventional topical formulations, which often result in sub-therapeutic concentrations, local toxicity, and poor tissue penetration. PATCH addresses these issues through the design of biocompatible hydrogels, the standardization of their physicochemical properties, the modulation of crosslinking density, the development of antibiotic loading strategies, and the definition of controlled-release profiles adaptable to different wound types.

The planned validation integrates analytical characterization, stability studies, biocompatibility assays, antimicrobial efficacy testing, and in vivo models, with the aim of generating a scalable and translational platform. In this perspective, PATCH represents a key contribution to the MARE therapeutic pipeline, translating expertise in materials chemistry and advanced formulation into a biomedical solution with substantial clinical and industrial potential.